QWO (collagenase clostridium histolyticum-aaes) is the first and only FDA-approved injectable for the treatment of moderate to severe cellulite in the buttocks of adult women. QWO (pronounced kwhoa) contains two types of collagen-degrading enzymes that eat away at the fibrous bands (or fibrous septae) connecting skin to muscle, gradually dissolving the tethers and allowing the skin to float up and smooth out.
What is Cellulite?
Cellulite is a localized alteration in the contour of the skin that has been reported in approximately 90% of adult women of all races and ethnicities.
What Causes Cellulite?
Over time, three completely normal things can happen. Fat cells get larger, skin gets thinner and a little looser and the fibrous bands under the skin’s surface get thicker, leading to a dimpled appearance.
Who Gets Cellulite?
Women are more likely to have cellulite than men, and it affects women of all shapes, sizes, ages, and races.
Why aren't men prone to developing cellulite?
Men have thicker skin than women do, and their collagen bands are oriented in a crisscross fashion, essentially eliminating the ability of the fat lobules to bulge through. If a man is given estrogen hormones (as in some cancer treatments), they can develop cellulite if there is enough fat.
Are Fat and Cellulite the Same?
Fat is not cellulite and does not cause it, but fat cells getting bigger between fibrous bands under the skin can contribute to a bumpy appearance.
How Does QWO Work?
Enzymes called collagenases target the structural causes under the skin, where cellulite starts. It’s thought that QWO works by releasing fibrous bands, redistributing fat cells, and stimulating the growth of new collagen. How QWO works in moderate to severe cellulite is not fully understood.
Is QWO a Surgical Procedure?
No. QWO is an injectable treatment option that is thought to target a primary structural cause of cellulite— the fibrous septae. The exact mechanism for the treatment of moderate to severe cellulite is unknown.
Can QWO be used to treat cellulite in other areas besides the buttocks?
QWO is only approved for treatment of moderate to severe cellulite in the buttocks of adult women. Endo Aesthetics is continuing to investigate additional areas of treatment.
How many treatments will I need?
Each treatment visit may include up to two treatment areas. QWO injections will be given three weeks apart for a total of three treatment visits.